Our research goes in MRSA screening, MRSA nasal, MRSA and more..

ContraFect Announces U.S. FDA Grants Breakthrough Therapy Designation to Exebacase for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia, Including Right-Sided Endocarditis

MRSA spreads easily in household environments

ContraFect: A Game-Changing Treatment For The Superbug MRSA

Earlier initiation of combination therapy is beneficial in MRSA bacteremia

Preliminary Negative Cultures for the De-Escalation of MRSA Therapy

Newly Approved Test Can Diagnose MRSA in 5 Hours

Utility of MRSA-Positive Nasal Samples in Antimicrobial Stewardship

Can we reverse antibiotic resistance?

Certain Healthcare Personnel Patient Interactions Carry Higher Risk of MRSA
Transmission

Some people have better genetic protection from MRSA

Smoking makes MRSA superbugs more resistant to antibiotics

Survey: Hospitals Increasing Support for Antibiotic Stewardship

S. aureus prevalent on cell phones of nursing students

‘Superbugs’ Found on Patients’ Hands and What They Touch

MULTIDRUG-RESISTANT INFECTIONS CAN COST $4,600 PER HOSPITAL STAY

CDC: Progress stalled against staph, MRSA infections

Are we 'approaching an era where no antibiotics work?'

Scientists Develop New Method To Prevent MRSA

Study: Ambulance equipment likely contaminated with MRSA superbug

Trial supports use of topical antibiotics in NICU babies

A team of doctors led by Karen L. Kotloff, M.D., University of Maryland School of Medicine (UMSOM), Center for Vaccine Development and Global Health (CVD), has performed a clinical trial involving multiple hospitals that tested the effectiveness of applying a topical antibiotic known as mupirocin for prevention of Staphylococcus aureus (SA) infection in babies in the neonatal intensive care unit (NICU).
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Methicillin-resistant Staphylococcus aureus: livestock-associated, antimicrobial, and heavy metal resistance

MRSA case reported at local school district

MRSA and other germs linger in hospital curtains, linens

BioMerieux Recalls VITEK 2 Gram Positive Antimicrobial Susceptibility Testing (AST) Cards Due to False Results for some strains of methicillin-resistant Staphylococcus aureus (MRSA)

MRSA colonization significantly increases risk of subsequent infection

Influenza-MRSA Co-Infection May Require Vancomycin Plus Second Antibiotic

MRSA Fast Facts – CNN – CNN.com

Impact of MRSA on the military medical service and diagnostic point-of-care options for the field setting

Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus (MRSA) Infection

Using MRSA's strength against it

Multiple Cross Displacement Amplification Coupled With Nanoparticles-Based Lateral Flow Biosensor for Detection of Staphylococcus aureus and Identification of Methicillin-Resistant S. aureus

International MRSA testing week - April 1-7 - MRSA screening saves lives

Newly discovered antibiotic drug offers hope for treating MRSA

Development of a paper-based vertical flow SERS assay for citrulline detection using aptamer-conjugated gold nanoparticles

New research suggests your own immune system can protect against MRSA infections

Researchers reveal how the MRSA bacterium handles stress

Study reveals how MRSA infection compromises lymphatic function

Selection of an aptamer against Muscovy duck parvovirus for highly sensitive rapid visual detection by label-free aptasensor

Site-specific aptamer inhibitors of Thermus RNA polymerase

Selection of DNA aptamers against Mycobacterium tuberculosis Ag85A, and its application in a graphene oxide-based fluorometric assay

Systematic optimization of L-tryptophan riboswitches for efficient monitoring of the metabolite in Escherichia coli

Distinguishing closely-related amyloid precursors using an RNA aptamer

This paper describes an aptamer capable of discriminating between monomeric human β2-microglobulin and its closely related amyloidogenic counterpart. Studies reveal that the aptamer alters the kinetics of co-polymerization of the two proteins, suggesting the potential of RNA aptamers as tools for studying the mechanisms of amyloid formation as well as being able to interfere in disease associated processes.
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Selection of 2’F-modified RNA aptamers against prostate-specific antigen and their evaluation for diagnostic and therapeutic applications

An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.

Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays

Aminoglycoside antibiotics are commonly used to treat livestock for a range of bacterial infections. However, they are also toxic to humans when in sufficient amounts. For this reason it is important to screen for these compounds in food stuffs. Here aptamers were selected against several combinations of Aminoglycosides to produce panel of ‘class specific’ aptamers for broad detection of multiple residues. These Aptamers were conjugated to gold nanoparticles to generate a simple colour change assay, demonstrating the potential for use as a rapid and cheap detection kit.
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Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides.

Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein.

Several RNA aptamers were generated against the Human papillomavirus E7 oncoprotien, which has been identified as a key causative agent of cervical cancer. Here, studies demonstrated the effects of minor aptamer variants and their ability to disrupting interactions between E7 and is major binding partner pRb. Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein.
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Development of aptamer therapeutics.

Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex.

Development of aptamers against key proteins can help to further research into understanding complex diseases such as cancer. In this paper RNA aptamers were isolated against the leukaemia associated DNA binding protein, RUNX1. These aptamers were shown to bind with high affinity and disrupt interactions between RUNX1 and its target DNA binding sequence in both a purified protein and a crude nuclear extract. This suggests a role for aptamers in the study of proteins and protein complexes and their involvement in disease.
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Production and characterization of RNA aptamers specific for amyloid fibril epitopes.

More than 20 human diseases including Alzheimer’s, Parkinson’s and Huntington’s disease, have been linked with the deposition of insoluble, misfolded proteins (collectively referred to as amyloidoses). This paper describes the isolation and characterisation of RNA aptamers against the amyloid fibrils associated with dialysis-related amyloidosis. These aptamers demonstrated the ability to discriminate between native and amyloid conformations of the target, as well as recognising material from patient tissue samples. This demonstrates the ability of aptamers to discriminate between different folds of the same amino acid sequence.
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Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.

Foot and mouth disease is a well document viral disease known to have cost the UK economy approximately £8 billion in the 2001 outbreak. Due to its economic impact, RNA aptamers were developed to serve as research tools against key viral proteins. Here a high affinity aptamer (18-75nM) against the viral RNA polymerase demonstrated an inhibitory effect, suggesting possible use as research tools or even potentially as a therapeutic.
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Aptamers come of age – at last.

A short introductory literature review of Aptamers since their inception in the 1990s; highlighting the use of aptamers in the areas such as diagnostics, therapeutics and research regents. This article underlines some of the benefits of Aptamers over antibodies including their ability to be chemical synthesised instead of requiring animals and relative ease with which they can be modified to extend their half-life in biological fluids.
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APTASURE – INDUSTRY RESEARCH